Article
Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment.
Oncogene - 1 Jan 2024
Dong Xiang, Li Chunlu, Deng Chengsi, Liu Jingwei, Li Danni, Zhou Tingting, Yang Xindi, Liu Yunchan, Guo Qiqiang, Feng Yanling, Yu Yang, Wang Zhuo, Guo Wendong, Zhang Siyi, Cui Hongyan, Jiang Cui, Wang Xiwen, Song Xiaoyu, Sun Xun, Cao Liu
Abstract excerpt
Several studies have demonstrated the role of the oncogenic mutant p53 in promoting tumor progression; however, there is limited information on the effects of secreted oncogenic mutant p53 on the tumor microenvironment and tumor immune escape. In this study, we found that secretion of mutant p53, determined by exosome content, is dependent on its N-terminal dileucine motif via its binding to β-adaptin, and...
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