The crisscross between p53 and metabolism in cancer.

Abstract excerpt

As the guardian of the genome, p53 is well known for its tumor suppressor function in humans, controlling cell proliferation, senescence, DNA repair and cell death in cancer through transcriptional and non-transcriptional activities. p53 is the most frequently mutated gene in human cancer, but how its mutation or depletion leads to tumorigenesis still remains poorly understood. Recently, there has been increasing...

Topics

• Humans
• Tumor Suppressor Protein p53
• Neoplasms
• Carcinogenesis
• Mutation
• Energy Metabolism