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Article

Tumour-associated mutant p53 drives the Warburg effect.

Nature communications - 1 Jan 2013

Zhang Cen, Liu Juan, Liang Yingjian, Wu Rui, Zhao Yuhan, Hong Xuehui, Lin Meihua, Yu Haiyang, Liu Lianxin, Levine Arnold J, Hu Wenwei, Feng Zhaohui

Abstract excerpt

Tumour cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect. Its mechanism is not well understood. The tumour suppressor gene p53 is frequently mutated in tumours. Many tumour-associated mutant p53 (mutp53) proteins not only lose tumour suppressive function but also gain new oncogenic functions that are independent of wild-type p53, defined as mutp53 gain of...

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Identifiers

PMID: 24343302
DOI: 10.1038/ncomms3935
PMCID: PMC3969270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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