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Article

p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant

13 Nov 2018

Abstract excerpt

BACKGROUND: In response to oncogenic stress, the tumour suppressor protein p53 can induce the elimination of cells through induction of cell death or senescence, helping to restrain malignant progression. Conversely, under nutrient stress, p53 can protect cells by supporting metabolic adaptation. Many cancers express mutant p53 proteins that have lost the cell-elimination properties of wild-type p53. However, a...

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PMID: 30524726
DOI: 10.1186/s40170-018-0191-6

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