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Article

Pneumocystis infection alters the activation state of pulmonary macrophages.

Immunobiology - 1 Feb 2017

Deckman Jessica M, Kurkjian Cathryn J, McGillis Joseph P, Cory Theodore J, Birket Susan E, Schutzman Linda M, Murphy Brian S, Garvy Beth A, Feola David J

Abstract excerpt

Recent studies show a substantial incidence of Pneumocystis jirovecii colonization and infection in patients with chronic inflammatory lung conditions. However, little is known about the impact of Pneumocystis upon the regulation of pulmonary immunity. We demonstrate here that Pneumocystis polarizes macrophages towards an alternatively activated macrophage-like phenotype. Genetically engineered mice that lack the...

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Identifiers

PMID: 27720434
DOI: 10.1016/j.imbio.2016.10.003
PMCID: PMC5154897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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