Article

Two parallel lineage-committed progenitors contribute to the developing brain

2025-07-03

Abstract excerpt

The hindbrain is a life-sustaining brain region. In one model, a common neural progenitor generates all brain regions. Here our studies of mouse embryos and human pluripotent stem cells (hPSCs) support a different model: two parallel brain progenitors emerge simultaneously during gastrulation, anterior neural ectoderm (forebrain/midbrain progenitor) and posterior neural ectoderm (hindbrain progenitor). Not only ar...

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Literature Corpus work: ad5e9cd8-cc70-5997-b366-2ce232303e05
DOI: 10.1101/2025.07.02.662771

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