Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series.

doi:10.1186/s13073-016-0352-6

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Article

Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series.

Genome medicine - 30 Sept 2016

Dumas Marc-Emmanuel, Domange Céline, Calderari Sophie, Martínez Andrea Rodríguez, Ayala Rafael, Wilder Steven P, Suárez-Zamorano Nicolas, Collins Stephan C, Wallis Robert H, Gu Quan, Wang Yulan, Hue Christophe, Otto Georg W, Argoud Karène, Navratil Vincent, Mitchell Steve C, Lindon John C, Holmes Elaine, Cazier Jean-Baptiste, Nicholson Jeremy K, Gauguier Dominique

Abstract excerpt

BACKGROUND: The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus occurs through complex organ-specific cellular mechanisms and networks contributing to impaired insulin secretion and insulin resistance. Genome-wide gene expression profiling systems can dissect the genetic contributions to metabolome and transcriptome regulations. The integrative analysis of multiple gene...

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PMID: 27716393
DOI: 10.1186/s13073-016-0352-6
PMCID: PMC5045612

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