Article
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling.
PLoS genetics - 14 Mar 2008
Ferrara Christine T, Wang Ping, Neto Elias Chaibub, Stevens Robert D, Bain James R, Wenner Brett R, Ilkayeva Olga R, Keller Mark P, Blasiole Daniel A, Kendziorski Christina, Yandell Brian S, Newgard Christopher B, Attie Alan D
Abstract excerpt
Although numerous quantitative trait loci (QTL) influencing disease-related phenotypes have been detected through gene mapping and positional cloning, identification of the individual gene(s) and molecular pathways leading to those phenotypes is often elusive. One way to improve understanding of genetic architecture is to classify phenotypes in greater depth by including transcriptional and metabolic profiling....
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