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Metabolic Network Topology Reveals Transcriptional Regulatory Signatures of Type 2 Diabetes

1 Apr 2010

Abstract excerpt

Type 2 diabetes mellitus (T2DM) is a disorder characterized by both insulin resistance and impaired insulin secretion. Recent transcriptomics studies related to T2DM have revealed changes in expression of a large number of metabolic genes in a variety of tissues. Identification of the molecular mechanisms underlying these transcriptional changes and their impact on the cellular metabolic phenotype is a...

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PMID: 20369014
DOI: 10.1371/journal.pcbi.1000729

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