Article
Systems genetics of metabolic health in the BXD mouse genetic reference population.
Cell systems - 19 Jun 2024
Li Xiaoxu, Morel Jean-David, Sulc Jonathan, De Masi Alessia, Lalou Amélia, Benegiamo Giorgia, Poisson Johanne, Liu Yasmine, Von Alvensleben Giacomo V G, Gao Arwen W, Bou Sleiman Maroun, Auwerx Johan
Abstract excerpt
Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic variation and lack specific evaluation criteria for MetS. Here, we derived a continuous metric, the metabolic health score (MHS), based on standard clinical...
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