Article
The pathologic effect of a novel neomorphic Fgf9(Y162C) allele is restricted to decreased vision and retarded lens growth.
PloS one - 1 Jan 2011
Puk Oliver, Möller Gabriele, Geerlof Arie, Krowiorz Kathrin, Ahmad Nafees, Wagner Sibylle, Adamski Jerzy, de Angelis Martin Hrabé, Graw Jochen
Abstract excerpt
Fibroblast growth factor (Fgf) signalling plays a crucial role in many developmental processes. Among the Fgf pathway ligands, Fgf9 (UniProt: P54130) has been demonstrated to participate in maturation of various organs and tissues including skeleton, testes, lung, heart, and eye. Here we establish a novel Fgf9 allele, discovered in a dominant N-ethyl-N-nitrosourea (ENU) screen for eye-size abnormalities using the...
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