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Article

Eye-open at birth phenotype with reduced keratinocyte motility in LGR4 null mice.

FEBS letters - 2 Oct 2007

Kato Shigeki, Mohri Yasuaki, Matsuo Tsuyoshi, Ogawa Eisaku, Umezawa Akihiro, Okuyama Ryuhei, Nishimori Katsuhiko

Abstract excerpt

We observed a consistent eye-open at birth (EOB) phenotype in mouse pups homozygous for a leucine-rich repeat containing G-protein coupled receptor 4 (Lgr4) allele deleting the whole transmembrane domain coding region. An in vitro wound-healing scratch assay showed notably reduced keratinocyte motility in the null mice. Phalloidin staining of F-actin in the eyelid epidermis was also reduced. We also generated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 17850793
DOI: 10.1016/j.febslet.2007.08.064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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