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Article

Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.

EMBO reports - 1 Nov 2016

Asaoka Tomoko, Almagro Jorge, Ehrhardt Christine, Tsai Isabella, Schleiffer Alexander, Deszcz Luiza, Junttila Sini, Ringrose Leonie, Mechtler Karl, Kavirayani Anoop, Gyenesei Attila, Hofmann Kay, Duchek Peter, Rittinger Katrin, Ikeda Fumiyo

Abstract excerpt

The HOIP ubiquitin E3 ligase generates linear ubiquitin chains by forming a complex with HOIL-1L and SHARPIN in mammals. Here, we provide the first evidence of linear ubiquitination induced by a HOIP orthologue in Drosophila We identify Drosophila CG11321, which we named Linear Ubiquitin E3 ligase (LUBEL), and find that it catalyzes linear ubiquitination in vitro We detect endogenous linear ubiquitin...

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Source

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Identifiers

PMID: 27702987
DOI: 10.15252/embr.201642378
PMCID: PMC5090701

Genes

SHARPIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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