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LUBAC-mediated linear ubiquitination in tissue homeostasis and disease

5 Jun 2023

Abstract excerpt

In addition to its role in the ubiquitin-proteasome system of protein degradation, polyubiquitination is involved in the regulation of intracellular events. Depending on the type of ubiquitin-ubiquitin linkage used, polyubiquitin can assume several types of structures. The spatiotemporal dynamics of polyubiquitin involve multiple adaptor proteins and induce different downstream outputs. Linear ubiquitination, in...

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PMID: 37279649
DOI: 10.1093/jb/mvad045

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