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Article

Elucidation of Ubiquitin-Related Functions via an Ubiquitin Overexpression Approach.

Cells - 5 Dec 2024

Masuda Ryo, Yoshikawa Munetaka, Moriuchi Ryota, Oba Yumiko, Dohra Hideo, Kimura Yoko

Abstract excerpt

To identify new ubiquitin-related functions using yeast, we searched for mutants conferring a temperature-sensitivity phenotype that could be rescued through ubiquitin overexpression. Screening of mutants using this overexpression strategy identified SPC2, which encodes a subunit of the endoplasmic reticulum (ER) signal peptidase complex (SPC). Ubiquitin overexpression rescued a high-temperature sensitivity of...

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PMID: 39682759
DOI: 10.3390/cells13232011
PMCID: PMC11639773

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