Article
Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis.
Nature communications - 18 Nov 2016
Teh Charis E, Lalaoui Najoua, Jain Reema, Policheni Antonia N, Heinlein Melanie, Alvarez-Diaz Silvia, Sheridan Julie M, Rieser Eva, Deuser Stefanie, Darding Maurice, Koay Hui-Fern, Hu Yifang, Kupresanin Fiona, O'Reilly Lorraine A, Godfrey Dale I, Smyth Gordon K, Bouillet Philippe, Strasser Andreas, Walczak Henning, Silke John, Gray Daniel H D
Abstract excerpt
The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymocyte differentiation, FOXP3+ regulatory T (Treg)-cell development and Treg cell homeostasis. LUBAC activity is not required to prevent TNF-induced apoptosis or...
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