LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling

Abstract excerpt

Ubiquitination is a reversible post-translational modification in which ubiquitin chains are conjugated to target proteins to modulate protein function. The type of ubiquitin chain determines the mode of protein regulation. It has been shown that ubiquitin chains are formed via one of seven Lys residues in ubiquitin, and several types of ubiquitin chains are found in cells. We identified a new type of linear...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to interferon and immune responses
• Share to Peptidase Inhibition and Analysis
• Share to Ubiquitin and proteasome pathways