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Article

Impact of R264C and R264H polymorphisms in human aromatase function.

The Journal of steroid biochemistry and molecular biology - 1 Mar 2017

Baravalle Roberta, Di Nardo Giovanna, Bandino Andrea, Barone Ines, Catalano Stefania, Andò Sebastiano, Gilardi Gianfranco

Abstract excerpt

The cytochrome P450 aromatase is involved in the last step of sex hormones biosynthesis by converting androgens into estrogens. The human enzyme is highly polymorphic and literature data correlate aromatase single nucleotide polymorphisms to the onset of pathologies such as breast cancer and neurodegenerative diseases. The aims of this study were i) to study the influence of the mutations R264C and R264H on the...

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Identifiers

PMID: 27702664
DOI: 10.1016/j.jsbmb.2016.09.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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