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Article

Functional characterization of the G162R and D216H genetic variants of human CYP17A1.

The Journal of steroid biochemistry and molecular biology - 1 Apr 2018

Capper C P, Liu J, McIntosh L R, Larios J M, Johnson M D, Hollenberg P F, Osawa Y, Auchus R J, Rae J M

Abstract excerpt

Cytochrome P450 17A1 (CYP17A1) is a dual-function enzyme catalyzing reactions necessary for cortisol and androgen biosynthesis. CYP17A1 is a validated drug target for prostate cancer as CYP17A1 inhibition significantly reduces circulating androgens and improves survival in castration-resistant prostate cancer. Germline CYP17A1 genetic variants with altered CYP17A1 activity manifesting as various endocrinopathies...

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Identifiers

PMID: 29229304
DOI: 10.1016/j.jsbmb.2017.12.002
PMCID: PMC5835412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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