Article
Evidence for an elevated aspartate pK(a) in the active site of human aromatase.
The Journal of biological chemistry - 9 Jan 2015
Di Nardo Giovanna, Breitner Maximilian, Bandino Andrea, Ghosh Debashis, Jennings Gareth K, Hackett John C, Gilardi Gianfranco
Abstract excerpt
Aromatase (CYP19A1), the enzyme that converts androgens to estrogens, is of significant mechanistic and therapeutic interest. Crystal structures and computational studies of this enzyme shed light on the critical role of Asp(309) in substrate binding and catalysis. These studies predicted an elevated pK(a) for Asp(309) and proposed that protonation of this residue was required for function. In this study,...
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