Article

Polymorphism on human aromatase affects protein dynamics and substrate binding: spectroscopic evidence.

2021-04-09

Abstract excerpt

Human aromatase is a member of the cytochrome P450 superfamily, involved in steroid hormones biosynthesis. In particular, it converts androgen into estrogens being therefore responsible for the correct sex steroids balance. Due to its capacity in producing estrogens it has also been considered as a promising target for breast cancer therapy. Two single-nucleotide polymorphisms (R264C and R264H) have been shown to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd3f7c74-ba6b-5a91-b556-9171c1230d61
DOI: 10.21203/rs.3.rs-385816/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polymorphism on human aromatase affects protein dynamics and substrate binding: spectroscopic evidence.DOI 10.21203/rs.3.rs-385816/v1Read

Impact of R264C and R264H polymorphisms in human aromatase function.Semantic proximity Read

Molecular insights into CYP19A1 mutations and their role in estrogen production.Semantic proximity Read

In silico analysis of nsSNPs in CYP19A1 gene affecting breast cancer associated aromatase enzyme.Semantic proximity Read

Variant of uncertain significance Arg866Cys enhances disorderedness of h-BRCA1 (759-1064) region.Semantic proximity Read

Loss of multiple enzyme activities due to the human genetic variation P284T in NADPH cytochrome P450 oxidoreductaseSemantic proximity Read

Analysis of the complex formation, interaction and electron transfer pathway between the "open" conformation of NADPH-cytochrome P450 reductase and aromatase.Semantic proximity Read

Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 OxidoreductaseSemantic proximity Read

Three‐dimensional model of the human aromatase enzyme and density functional parameterization of the iron‐containing protoporphyrin IX for a molecular dynamics study of heme‐cysteinato cytochromesSemantic proximity Read

An in silico approach to investigate the source of the controversial interpretations about the phenotypic results of the human AhR-gene G1661A polymorphism.Semantic proximity Read

Molecular interaction between steroid sulfatases and formylglycine generating enzyme: A computational study with multiple mutationsSemantic proximity Read

Structural and Dynamic Characterizations Highlight the Deleterious Role of SULT1A1 R213H Polymorphism in Substrate Binding.Semantic proximity Read

Phosphorylation of human placental aromatase CYP19A1Semantic proximity Read