Article
Human platelet 12-lipoxygenase: naturally occurring Q261/R261 variants and N544L mutant show altered activity but unaffected substrate binding and membrane association behavior.
International journal of molecular medicine - 1 Dec 2009
Aleem Ansari M, Wells Leigh, Jankun Jerzy, Walther Matthias, Kühn Hartmut, Reinartz Jeannette, Skrzypczak-Jankun Ewa
Abstract excerpt
The single nucleotide polymorphism (SNP) R261Q in the human platelet 12-lipoxygenase has been correlated with several human diseases. To understand better the biological performance we have compared enzymatic properties of the recombinant enzymes: 'wild-type' as Q261 and R261 variants with a single Q261R mutation at the enzyme periphery and N544L mutant with an altered active site. The R261 variant does not...
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