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Article

Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H.

The Journal of steroid biochemistry and molecular biology - 1 Feb 2020

Parween Shaheena, DiNardo Giovanna, Baj Francesca, Zhang Chao, Gilardi Gianfranco, Pandey Amit V

Abstract excerpt

Aromatase (CYP19A1) converts androgens into estrogens and is required for female sexual development and growth and development in both sexes. CYP19A1 is a member of cytochrome P450 family of heme-thiolate monooxygenases located in the endoplasmic reticulum and depends on reducing equivalents from the reduced nicotinamide adenine dinucleotide phosphate via the cytochrome P450 oxidoreductase coded by POR. Both the...

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PMID: 31669572
DOI: 10.1016/j.jsbmb.2019.105507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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