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Article

Molecular insights into CYP19A1 mutations and their role in estrogen production.

Archives of biochemistry and biophysics - 1 Oct 2025

Lee Yoo-Bin, Kim Changmin, Hong Jiyeon, Kim Donghak

Abstract excerpt

Human cytochrome P450 enzyme CYP19A1, commonly referred to as aromatase, plays a critical role in estrogen biosynthesis by catalyzing the conversion of C19 androgens into aromatic C18 estrogens. Alterations in aromatase activity have been implicated in the development and progression of estrogen-dependent diseases. Genetic mutations, including nonsynonymous single nucleotide polymorphisms (SNPs), can markedly...

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Identifiers

PMID: 40744254
DOI: 10.1016/j.abb.2025.110573

Genes

CYP19A1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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