Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In silico analysis of nsSNPs in CYP19A1 gene affecting breast cancer associated aromatase enzyme.

Journal of genetics - 1 Jan 2021

Pavithran Honey, Kumavath Ranjith

Abstract excerpt

The human aromatase protein encoded by CYP19A1 gene is the principle enzyme involved in the biogenesis of oestrogen in adipose tissues. An excessive exposure to endogenous oestrogen is regarded as an important determinant in the risk of breast cancer. Thus, in the present study we have used multiple computational methods to identify the most deleterious nonsynonymous SNPs in CYP19A1 gene that caused probable...

Topics

Aromatase
Breast Neoplasms
Computational Biology
Computer Simulation
Female
Genetic Predisposition to Disease
Humans
Mutation, Missense
Polymorphism, Single Nucleotide
Software

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34187970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In silico analysis of nsSNPs in CYP19A1 gene affecting breast cancer associated aromatase enzyme.PMID 34187970Read ↗

In-Silico Investigation of Effects of Single-Nucleotide Polymorphisms in PCOS-Associated CYP11A1 Gene on Mutated Proteins.Semantic proximity Read ↗

Structural modeling and in silico analysis of non-synonymous single nucleotide polymorphisms of human 3β-hydroxysteroid dehydrogenase type 2Semantic proximity Read ↗

Impact of Missense Variants on the Structure and Function of Polycystic Ovary Syndrome-Associated HSD17B1 Gene.Semantic proximity Read ↗

Performance of in silico analysis in predicting the effect of non-synonymous variants in inherited steroid metabolic diseases.Semantic proximity Read ↗

Functional genomics based prioritization of potential nsSNPs in EPHX1, GSTT1, GSTM1 and GSTP1 genes for breast cancer susceptibility studies.Semantic proximity Read ↗

In-Silico Analysis of nsSNPs Associated with CYP11B2 GeneSemantic proximity Read ↗

Human gene mutations. Gene symbol: CYP19. Disease: Aromatase deficiency.Semantic proximity Read ↗

Human aromatase: gene resequencing and functional genomics.Semantic proximity Read ↗

Molecular insights into CYP19A1 mutations and their role in estrogen production.Semantic proximity Read ↗

A Novel Null Mutation in P450 Aromatase Gene (CYP19A1) Associated with Development of Hypoplastic Ovaries in HumansSemantic proximity Read ↗

In silico analysis of nsSNPs in ABCB1 gene affecting breast cancer associated protein P-glycoprotein (P-gp).Semantic proximity Read ↗

Significance of the Estrogen Hormone and Single Nucleotide Polymorphisms in the Progression of Breast Cancer among Female.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.