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Article

Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study.

International journal of geriatric psychiatry - 1 Dec 2017

Takeshita Yoshihide, Shibata Nobuto, Kasanuki Koji, Nagata Tomoyuki, Shinagawa Shunichiro, Kobayashi Nobuyuki, Ohnuma Tohru, Suzuki Ayako, Kawai Eri, Takayama Toshiki, Nishioka Kenya, Motoi Yumiko, Hattori Nobutaka, Nakayama Kazuhiko, Yamada Hisashi, Arai Heii

Abstract excerpt

BACKGROUND/AIMS: Interaction of receptor for advanced glycation end products (RAGE) with amyloid-β increases amplification of oxidative stress and plays pathological roles in Alzheimer's disease (AD). Oxidative stress leads to α-synuclein aggregation and is also a major contributing factor in the pathogenesis of Lewy body dementias (LBDs). Therefore, we aimed to investigate whether RAGE gene polymorphisms were...

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Identifiers

PMID: 27699858
DOI: 10.1002/gps.4600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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