Association between the RAGE G82S polymorphism and Alzheimer's disease.

doi:10.1007/s00702-009-0334-6

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Article

Association between the RAGE G82S polymorphism and Alzheimer's disease.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2010

Li Keshen, Dai Dawei, Zhao Bin, Yao Lifen, Yao Songpo, Wang Binyou, Yang Ze

Abstract excerpt

The receptor for advanced glycation end products (RAGE) is associated with several pathological states including Alzheimer's disease (AD) pathology, while its soluble form (sRAGE) acts as a decoy receptor. We have tested for association of AD with a functional single-nucleotide polymorphism (SNP) in the RAGE gene (G82S; rs2070600), a SNP associated with increased ligand affinity of RAGE. Analysis of a Chinese...

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PMID: 19902324
DOI: 10.1007/s00702-009-0334-6

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