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Regulation of RAGE splicing by hn RNP A1 and Tra2β‐1 and its potential role in AD pathogenesis

17 Feb 2015

Abstract excerpt

The receptor for advanced glycation end products (RAGE) gene expresses two major alternative splicing isoforms, full-length membrane-bound RAGE (mRAGE) and secretory RAGE (esRAGE). Both isoforms play important roles in Alzheimer's disease (AD) pathogenesis, either via interaction of mRAGE with β-amyloid peptide (Aβ) or inhibition of the mRAGE-activated signaling pathway. In the present study, we showed that...

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PMID: 25689357
DOI: 10.1111/jnc.13069

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