Article
A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis.
Scientific reports - 31 Aug 2017
Díaz-Jiménez David, Núñez Lucía, De la Fuente Marjorie, Dubois-Camacho Karen, Sepúlveda Hugo, Montecino Martín, Torres-Riquelme Alejandro, García-González Paulina, Chnaiderman Jonás, Vossenkamper Anna, MacDonald Thomas T, Simian Daniela, González María-Julieta, Cidlowski John A, Quera Rodrigo, Hermoso Marcela A
Abstract excerpt
The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) with anti-inflammatory properties. In UC patients, sST2 is further increased by corticosteroid treatment; however, the glucocorticoid-mediated molecular regulation remains unknown. We therefore...
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