Article
Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase.
RNA (New York, N.Y.) - 1 Dec 2016
Freihofer Pietro, Akbergenov Rashid, Teo Youjin, Juskeviciene Reda, Andersson Dan I, Böttger Erik C
Abstract excerpt
Several studies over the last few decades have shown that antibiotic resistance mechanisms frequently confer a fitness cost and that these costs can be genetically ameliorated by intra- or extragenic second-site mutations, often without loss of resistance. Another, much less studied potential mechanism by which the fitness cost of antibiotic resistance could be reduced is via a regulatory response where the...
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