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Article

Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Feb 2005

Maus Courtney E, Plikaytis Bonnie B, Shinnick Thomas M

Abstract excerpt

Capreomycin, an important drug for the treatment of multidrug-resistant tuberculosis, is a macrocyclic peptide antibiotic produced by Saccharothrix mutabolis subspecies capreolus. The basis of resistance to this drug was investigated by isolating and characterizing capreomycin-resistant strains of Mycobacterium smegmatis and Mycobacterium tuberculosis. Colonies resistant to capreomycin were recovered from a...

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Identifiers

PMID: 15673735
DOI: 10.1128/AAC.49.2.571-577.2005
PMCID: PMC547314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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