Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinically relevant mutations in mycobacterial LepA cause rifampicin-specific phenotypic resistance.

Scientific reports - 21 May 2020

Wang Bi-Wei, Zhu Jun-Hao, Javid Babak

Abstract excerpt

Although all wild-type bacterial populations exhibit antibiotic tolerance, bacterial mutants with higher or lower tolerant subpopulation sizes have been described. We recently showed that in mycobacteria, phenotypically-resistant subpopulations can grow in bulk-lethal concentrations of rifampicin, a first-line anti-tuberculous antibiotic targeting RNA polymerase. Phenotypic resistance was partly mediated by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Drug Resistance, Bacterial
Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Mycobacterium smegmatis

Share to Peptide Initiation Factors

Share to Rifampin

Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 32439911
DOI: 10.1038/s41598-020-65308-2
PMCID: PMC7242378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinically relevant mutations in mycobacterial LepA cause rifampicin-specific phenotypic resistance.PMID 32439911Read ↗

Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes.Semantic proximity Read ↗

Genome scale CRISPRi reveals both shared and strain-specific vulnerabilities in genetically diverse drug-resistant strains of Mycobacterium tuberculosis.Semantic proximity Read ↗

The identification Mycobacterium tuberculosis genes that modulate long term survival in the presence of rifampicin and streptomycinSemantic proximity Read ↗

Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis.Semantic proximity Read ↗

Cell Wall Proteomics Reveal Phenotypic Adaption of Drug-Resistant Mycobacterium smegmatis to Subinhibitory Rifampicin ExposureSemantic proximity Read ↗

Alanine dependence of trans-translation contributes to riboregulation of mycobacterial antibiotic recalcitrance genesSemantic proximity Read ↗

Mutations in RNA polymerase that drive the emergence of antibiotic resistance.Semantic proximity Read ↗

Convergent Evolution Driven by Rifampin Exacerbates the Global Burden of Drug-Resistant Staphylococcus aureusSemantic proximity Read ↗

Mutations in rpoB That Confer Rifampicin Resistance Can Alter Levels of Peptidoglycan Precursors and Affect β-Lactam Susceptibility.Semantic proximity Read ↗

Resistance to rifampicin: a review.Semantic proximity Read ↗

Beyond Inhibition: Sublethal Rifampicin-Induced Molecular Adaptations Confer Phenotypic Drug Tolerance in Mycobacteria.Semantic proximity Read ↗

Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.