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Article

Gene-Gene Interactions Among PRKCA, NOS3 and BDKRB2 Polymorphisms Affect the Antihypertensive Effects of Enalapril.

Basic & clinical pharmacology & toxicology - 1 Mar 2017

Oliveira-Paula Gustavo H, Luizon Marcelo R, Lacchini Riccardo, Fontana Vanessa, Silva Pamela S, Biagi Celso, Tanus-Santos Jose E

Abstract excerpt

Protein kinase C (PKC) signalling is critically involved in the control of blood pressure. Angiotensin-converting enzyme inhibitors (ACEi) affect PKC expression and activity, which are partially associated with the responses to ACEi. We examined whether PRKCA (protein kinase C, alpha) polymorphisms (rs887797 C>T, rs1010544 T>C and rs16960228 G>A), or haplotypes, and gene-gene interactions within the ACEi pathway...

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Topics

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Share to Angiotensin-Converting Enzyme Inhibitors
Share to Antihypertensive Agents
Share to Blood Pressure
Share to Epistasis, Genetic
Share to Nitric Oxide Synthase Type III
Share to Pharmacogenomic Variants
Share to Protein Kinase C-alpha
Share to Receptor, Bradykinin B2

Source

Identifiers

PMID: 27696692
DOI: 10.1111/bcpt.12682

Genes

PRKCA
BDKRB2
NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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