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Article

Gene-gene interactions in the protein kinase C/endothelial nitric oxide synthase axis impact the hypotensive effects of propofol.

Basic & clinical pharmacology & toxicology - 1 Feb 2022

Oliveira-Paula Gustavo H, Pereira Daniela A, Pinheiro Lucas C, Ferreira Graziele C, Paula-Garcia Waynice N, Garcia Luis V, Lacchini Riccardo, Luizon Marcelo R, Tanus-Santos Jose E

Abstract excerpt

Anaesthesia with propofol is frequently associated with hypotension, which is at least partially attributable to increased nitric oxide (NO) formation derived from the activation of protein kinase C (PKC)/endothelial NO synthase (NOS3) axis. In this cross-sectional study, we tested whether PRKCA (which encodes PKCα) polymorphisms, or haplotypes, and interactions among PRKCA and NOS3 polymorphisms affect the...

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PMID: 34825477
DOI: 10.1111/bcpt.13691

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