Article
The KCNH2 genetic polymorphism (1956, C>T) is a novel biomarker that is associated with CCB and α,β-ADR blocker response in EH patients in China.
PloS one - 1 Jan 2013
He Fazhong, Luo Jianquan, Luo Zhiying, Fan Lan, He Yijing, Zhu Dingliang, Gao Jinping, Deng Sheng, Wang Yan, Qian Yuesheng, Zhou Honghao, Chen Xiaoping, Zhang Wei
Abstract excerpt
BACKGROUND: KCNH2 (hERG) potassium channels have an integral role in regulating the excitability of smooth muscle cells. Some pathways driven by angiotensin II, nitric oxide and adrenergic receptors blocker are involved in modulating the properties of KCNH2 potassium channels. And these pathways are closely related to blood pressure regulation. Therefore, we hypothesized that KCNH2 genetic polymorphisms may...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.