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Article

Study of hTERT and Histone 3 Mutations in Medulloblastoma.

Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2017

Viana-Pereira Marta, Almeida Gisele Caravina, Stavale João Norberto, Malheiro Susana, Clara Carlos, Lobo Patrícia, Pimentel José, Reis Rui Manuel

Abstract excerpt

Hotspot activating mutations of the telomerase reverse transcriptase (hTERT) promoter region were recently described in several tumor types. These mutations lead to enhanced expression of telomerase, being responsible for telomere maintenance and allowing continuous cell division. Additionally, there are alternative telomere maintenance mechanisms, associated with histone H3 mutations, responsible for disrupting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27694758
DOI: 10.1159/000448922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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