Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain.

doi:10.1093/neuonc/nox027

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Article

Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain.

Neuro-oncology - 1 Sept 2017

Gojo Johannes, Lötsch Daniela, Spiegl-Kreinecker Sabine, Pajtler Kristian W, Neumayer Katharina, Korbel Pia, Araki Asuka, Brandstetter Anita, Mohr Thomas, Hovestadt Volker, Chavez Lukas, Kirchhofer Dominik, Ricken Gerda, Stefanits Harald, Korshunov Andrey, Pfister Stefan M, Dieckmann Karin, Azizi Amedeo A, Czech Thomas, Filipits Martin, Kool Marcel, Peyrl Andreas, Slavc Irene, Berger Walter, Haberler Christine

Abstract excerpt

BACKGROUND: Ependymomas account for up to 10% of childhood CNS tumors and have a high rate of tumor recurrence despite gross total resection. Recently, classification into molecular ependymoma subgroups has been established, but the mechanisms underlying the aggressiveness of certain subtypes remain widely enigmatic. The aim of this study was to dissect the clinical and biological role of telomerase reactivation,...

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PMID: 28371821
DOI: 10.1093/neuonc/nox027
PMCID: PMC5570194

Genes

ETV3
RELA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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