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Article

Cerebellar high-grade gliomas do not present the same molecular alterations as supratentorial high-grade gliomas and may show histone H3 gene mutations.

Clinical neuropathology - 1 Jan 2000

Tauziède-Espariat Arnault, Saffroy Raphaël, Pagès Mélanie, Pallud Johan, Legrand Laurence, Besnard Aurore, Lacombe Joëlle, Lot Guillaume, Borha Alin, Tazi Sanaa, Adle-Biassette Homa, Polivka Marc, Lechapt Emmanuèle, Varlet Pascale

Abstract excerpt

Numerous molecular alterations have been described in supratentorial high-grade gliomas (1p19q co-deletion, IDH1/2, histone H3, hTERT promotor mutations, loss of ATRX) which have led to a new histomolecular classification of diffuse gliomas. We aimed at describing these alterations in a series of 19 adults with pure cerebellar high-grade gliomas. Systematic immunohistochemical analyses, including that of...

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Source

Identifiers

PMID: 29809131
DOI: 10.5414/NP301104

Genes

EGFR
IDH1
ATRX
PTEN
BRAF
FGFR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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