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Article

Expression level of hTERT is regulated by somatic mutation and common single nucleotide polymorphism at promoter region in glioblastoma.

Oncotarget - 30 May 2014

Park Chul-Kee, Lee Se-Hoon, Kim Ji Young, Kim Ja Eun, Kim Tae Min, Lee Soon-Tae, Choi Seung Hong, Park Sung-Hye, Kim Il Han

Abstract excerpt

We investigated the role of somatic mutations and a common single nucleotide polymorphism (SNP) in the hTERT promoter region on hTERT expression and clinical outcomes. The hTERT promoter region was sequenced from 48 glioblastomas. hTERT expression was analyzed by quantitative real time-PCR. The association between hTERT promoter genetic changes and other genomic events and clinical variables common in gliomas...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24930669
DOI: 10.18632/oncotarget.1975
PMCID: PMC4102818

Genes

EGFR
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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