Article
Renal phenotype of ET-1 transgenic mice is modulated by androgens.
European journal of medical research - 1 Jan 2009
Kalk P, Thöne-Reineke C, Schwarz A, Godes M, Bauer C, Pfab T, Hocher B
Abstract excerpt
INTRODUCTION: Activation of the endothelin (ET) system promotes inflammation and fibrosis in various tissues including the kidney. Male ET-1 transgenic mice are characterized by chronic kidney inflammation and renal scarring. We hypothesized that this renal phenotype might be modulated by androge...
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