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Article

Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans.

Aging - 9 Sept 2021

Matei Ioan Valentin, Samukange Vimbai Netsai Charity, Bunu Gabriela, Toren Dmitri, Ghenea Simona, Tacutu Robi

Abstract excerpt

Genetic manipulations can ameliorate the aging process and extend the lifespan of model organisms. The aim of this research was to identify novel genetic interventions that promote both lifespan and healthspan, by combining the effects of multiple longevity-associated gene inactivations in C. elegans. For this, the individual and combined effects of the odr-3 mutation and of ife-2 and cku-70 knock-downs were...

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Identifiers

PMID: 34506301
DOI: 10.18632/aging.203518
PMCID: PMC8457566

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