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Article

Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice.

JCI insight - 23 Aug 2018

Bao Jianqiang, Perez Carlos J, Kim Jeesun, Zhang Huan, Murphy Caitlin J, Hamidi Tewfik, Jaubert Jean, Platt Craig D, Chou Janet, Deng Meichun, Zhou Meng-Hua, Huang Yuying, Gaitán-Peñas Héctor, Guénet Jean-Louis, Lin Kevin, Lu Yue, Chen Taiping, Bedford Mark T, Dent Sharon Yr, Richburg John H, Estévez Raúl, Pan Hui-Lin, Geha Raif S, Shi Qinghua, Benavides Fernando

Abstract excerpt

Ion channel-controlled cell volume regulation is of fundamental significance to the physiological function of sperm. In addition to volume regulation, LRRC8A-dependent volume-regulated anion channel (VRAC) activity is involved in cell cycle progression, insulin signaling, and cisplatin resistance. Nevertheless, the contribution of LRRC8A and its dependent VRAC activity in the germ cell lineage remain unknown. By...

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PMID: 30135305
DOI: 10.1172/jci.insight.99767
PMCID: PMC6141173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice.PMID 30135305Read ↗

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