Thymidylate synthase polymorphism in Mexican patients with colon cancer treated with 5-fluorouracil.

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Thymidylate synthase polymorphism in Mexican patients with colon cancer treated with 5-fluorouracil.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Jan 2000

Patricia Rios-Ibarra Clara, Janeth Rodriguez-Silva Claudia, Alonso Lopez-Chuken Yamil, Ortiz-Lopez Rocio, Fernandez-Castillo Elisa, Beatriz Del Toro Runzer Claudia, Paul Armenta-Perez Vicente, Flores-Gutierrez Juan Pablo, Quintanilla-Guzman Arturo, Salinas-Santander Mauricio, Gonzalez-Guerrero Juan Francisco, Bosques-Padilla Francisco, Santos Arturo, Guadalupe Martinez-Rodriguez Herminia

Abstract excerpt

PURPOSE: We analyzed the genotype and allele frequency of variable number tandem repeats (VNTR)-thymidylate synthase (TS) and its relationship with the disease evolution in colon cancer patients. METHODS: We selected 24 paraffin-embedded colon cancer tissue samples from Mexican patients who received a 5-fluorouracil (5-FU)-based chemotherapy regimen. Tumor tissue was digested with proteinase K and genomic DNA was...

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PMID: 27685916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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