Article
Thymidylate synthase polymorphism and microsatellite instability: association in colorectal cancer.
Nucleosides, nucleotides & nucleic acids - 1 Oct 2004
Calascibetta A, Rausa L, Gullotti L, Buettner R, Sanguedolce R
Abstract excerpt
5-Fluorouracil (5FU) is the main drug used for the treatment of colorectal cancer (CRC) and Thymidilate Synthase (TS) is its target enzyme. TS gene has regulatory tandemly repeated sequences in its 5' and 3'untraslated region (5'-3' UTR). CRC often shows a kind of genomic instability called Microsatellite Instability (MSI) that is associated with TS levels and survival. Our data show that the genotype 2R/2R...
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