Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thymidylate synthase genotyping is more predictive for therapy response than immunohistochemistry in patients with colon cancer.

International journal of cancer - 15 Oct 2008

Gosens Marleen J, Moerland Elna, Lemmens Valery P, Rutten Harm T, Tan-Go Ivonne, van den Brule Adriaan J

Abstract excerpt

Thymidylate synthase (TS) is a potentially valuable marker for therapy response since it is the molecular target of 5-fluorouracil (5-FU). TS can be analyzed at the DNA (gene polymorphisms and amplification) and protein level (immunohistochemistry). This study investigated the predictive role of TS at the DNA and protein levels in patients with N(+) colon cancer (n = 38). Tumor and normal tissues were genotyped...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colonic Neoplasms
Share to Combined Modality Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorouracil

Share to Gene Amplification

Share to Leucovorin

Share to Loss of Heterozygosity

Share to Minisatellite Repeats

Share to Thymidylate Synthase

Source

Identifiers

PMID: 18661526
DOI: 10.1002/ijc.23740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymidylate synthase genotyping is more predictive for therapy response than immunohistochemistry in patients with colon cancer.PMID 18661526Read ↗

Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma.Semantic proximity Read ↗

Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer.Semantic proximity Read ↗

Polymorphism of thymidylate synthase gene associated with its protein expression in human colon cancer.Semantic proximity Read ↗

Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients.Semantic proximity Read ↗

Thymidylate synthase expression and genotype have no major impact on the clinical outcome of colorectal cancer patients treated with 5-fluorouracil.Semantic proximity Read ↗

G>C SNP of thymidylate synthase with respect to colorectal cancer.Semantic proximity Read ↗

Thymidylate synthase polymorphism in Mexican patients with colon cancer treated with 5-fluorouracil.Semantic proximity Read ↗

Correlation between thymidylate synthase gene variants, RNA and protein levels in primary colorectal adenocarcinomas.Semantic proximity Read ↗

Do thymidylate synthase gene promoter polymorphism and the C/G single nucleotide polymorphism predict effectiveness of adjuvant 5-fluorouracil-based chemotherapy in stage III colonic adenocarcinoma?Semantic proximity Read ↗

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy.Semantic proximity Read ↗

Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients.Semantic proximity Read ↗

Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.