Article
Polymorphism of thymidylate synthase gene associated with its protein expression in human colon cancer.
World journal of gastroenterology - 28 Jan 2008
Yu Kai-Huan, Wang Wei-Xing, Ding You-Ming, Li Hui, Wang Ze-Sheng
Abstract excerpt
AIM: To correlate the polymorphisms in the 5'-untranslated region with thymidylate synthase (TS) protein expression in Han Chinese colonic neoplasms. METHODS: Adenocarcinoma samples were from 68 patients who received no treatment before surgery. Tandem repeat length of TS gene was determined by PCR amplification of genomic DNA. Intratumoral TS protein expression was studied immunohistochemically in corresponding...
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