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Polymorphisms in the thymidylate synthase gene and risk of colorectal cancer.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Gao Chang-Ming, Ding Jian-Hua, Li Su-Ping, Liu Yan-Ting, Cao Hai-Xia, Wu Jian-Zhong, Tajima Kazuo

Abstract excerpt

To evaluate the relationship between polymorphisms (28 bp repeated sequences in 5'-UTR and 6-bp ins/ del in 3'-UTR) in then thymidylate synthetase gene (TS) and risk of colorectal, colon and rectal cancers, we conducted a case-control study with 315 cases of colorectal cancer and 439 population-based controls in Jiangsu province, China. TS genotypes were identified using PCR-RFLP (restriction fragment length...

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PMID: 23098521
DOI: 10.7314/apjcp.2012.13.8.4087

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