Article
Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2001
Kawakami K, Salonga D, Park J M, Danenberg K D, Uetake H, Brabender J, Omura K, Watanabe G, Danenberg P V
Abstract excerpt
PURPOSE: Thymidylate synthase (TS) is a target enzyme of 5-fluorouracil. Recently, the TS gene has been shown to contain a polymorphic tandem repeat sequence. The aim of this study was to determine whether differences in the number of tandem repeats could affect gene expression or mRNA translation. EXPERIMENTAL DESIGN: We quantified TS mRNA isolated from 130 colorectal cancer tissues by real-time reverse...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.