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Article

Senescent Carcinoma-Associated Fibroblasts Upregulate IL8 to Enhance Prometastatic Phenotypes.

Molecular cancer research : MCR - 1 Jan 2017

Wang Tao, Notta Faiyaz, Navab Roya, Joseph Joella, Ibrahimov Emin, Xu Jing, Zhu Chang-Qi, Borgida Ayelet, Gallinger Steven, Tsao Ming-Sound

Abstract excerpt

Carcinoma-associated fibroblasts (CAF) represent a significant component of pancreatic cancer stroma and are biologically implicated in tumor progression. However, evidence of both cancer-promoting and -restraining properties amongst CAFs suggests the possibility of multiple phenotypic subtypes. Here, it is demonstrated that senescent CAFs promote pancreatic cancer invasion and metastasis compared with...

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PMID: 27678171
DOI: 10.1158/1541-7786.MCR-16-0192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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