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Article

The Aging Microenvironment as a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer

2025-05-10

Abstract excerpt

Aging is a critical yet understudied determinant in pancreatic ductal adenocarcinoma (PDAC). Despite a strong epidemiological association with age, conventional PDAC preclinical models fail to capture the histopathological and stromal complexities that emerge in older organisms. Using an age-relevant syngeneic orthotopic model, we demonstrate that organismal aging accelerates PDAC progression and metastasis. Throu...

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Literature Corpus work
b8beb0e3-004e-5d6d-8f4e-2bc177226f9c
DOI
10.1101/2025.05.08.652966
Open publication

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